Does The use of leucocyte- and platelet-rich fibrin (L-PRF) enhance alveolar-ridge preservation?
Recent years have seen a significant increase in clinical interest in the use of leucocyte- and platelet-rich fibrin (L-PRF) in periodontal therapy, on the premise that its local application may speed up the healing process and help preserve the alveolar ridge.
This hypothesis was tested in a clinical trial that compared the local growth factor release pattern, early wound healing, and changes in alveolar ridge dimensions in extraction sockets treated with L-PRF for alveolar ridge preservation and in sockets that healed naturally.
They discovered that although L-PRF provided higher local concentrations in wound fluid, it did not change the growth-factor profile. However, neither did this result in improved soft-tissue healing nor offer any clinical advantages.
In this intra-individual randomised controlled clinical trial, the healing pattern did not vary between the groups. In this intra-individual randomised controlled clinical trial with a five-month follow-up, the healing patterns of the groups did not vary.
Wang, X., Fok, M. R., Pelekos, G., Jin, L., & Tonetti, M. S. (2022). Increased local concentrations of growth factors from leucocyte- and platelet-rich fibrin do not translate into improved alveolar ridge preservation: An intra-individual mechanistic randomized controlled trial. Journal of Clinical Periodontology, 49(9), 889–898. https://doi.org/10.1111/jcpe.13688